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Article

Epithelioid glioblastoma arising from pleomorphic xanthoastrocytoma with the BRAF V600E mutation.

Brain tumor pathology - 1 Jul 2014

Tanaka Shingo, Nakada Mitsutoshi, Nobusawa Sumihito, Suzuki Satoshi O, Sabit Hemragul, Miyashita Katsuyoshi, Hayashi Yutaka

Abstract excerpt

Pleomorphic xanthoastrocytoma (PXA) is classified by the World Health Organization as a grade II astrocytic tumor with relatively favorable prognosis among gliomas. A valine-to-glutamic acid substitution at position 600 of the serine/threonine-protein kinase BRAF (BRAF V600E) mutation, which is commonly found in PXA, has recently been detected in approximately 50% of all epithelioid glioblastoma (GBM) cases. We...

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PMID: 24894018
DOI: 10.1007/s10014-014-0192-2

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BRAF

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