Article
Identification of BRAF V600E Mutation in Cerebrospinal Fluid Aids in Diagnosing Leptomeningeal Carcinomatosis Arising From Pleomorphic Xanthoastrocytoma: A Case Report.
Cancer reports (Hoboken, N.J.) - 1 Mar 2026
D'Amico Randy S, Avancena Patricia, Kashanian Alon, Galvez Rosivel, Gruber Deborah, Saba Sami, Zlochower Avraham, Harshan Manju, Vojnic Morana
Abstract excerpt
BACKGROUND: Pleomorphic xanthoastrocytomas (PXAs) are rare primary central nervous system (CNS) tumors that appear heterogeneous on imaging and histology and typically cause headaches or seizures on initial presentation. Alongside high rates of favorable prognosis after surgical excision exist similarly high rates of recurrence. Leptomeningeal spread on recurrence is even rarer and more challenging to diagnose....
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