Article
Biological and therapeutic implications of multisector sequencing in newly diagnosed glioblastoma.
Neuro-oncology - 27 Mar 2018
Mahlokozera Tatenda, Vellimana Ananth K, Li Tiandao, Mao Diane D, Zohny Zohny S, Kim David H, Tran David D, Marcus Daniel S, Fouke Sarah J, Campian Jian L, Dunn Gavin P, Miller Christopher A, Kim Albert H
Abstract excerpt
Background: Diagnostic workflows for glioblastoma (GBM) patients increasingly include DNA sequencing-based analysis of a single tumor site following biopsy or resection. We hypothesized that sequencing of multiple sectors within a given tumor would provide a more comprehensive representation of the molecular landscape and potentially inform therapeutic strategies. Methods: Ten newly diagnosed, isocitrate...
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