Article
Environmental determinants of type 1 diabetes: a role for overweight and insulin resistance.
Journal of paediatrics and child health - 1 Nov 2014
Islam Sadia T, Srinivasan Shubha, Craig Maria E
Abstract excerpt
Rates of type 1 diabetes are rising globally, with a decreasing proportion of high-risk genotypes and twin concordance rates below 50%. Therefore, environmental factors such as viruses, nutrition and overweight have been examined as putative aetiological agents. The accelerator hypothesis proposes that overweight and insulin resistance are central to both type 1 and type 2 diabetes and may explain, in part, the...
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