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Article

Temperament and character in remitted and symptomatic patients with schizophrenia: modulation by the COMT Val158Met genotype.

Journal of psychiatric research - 1 Sept 2014

Hori Hiroaki, Fujii Takashi, Yamamoto Noriko, Teraishi Toshiya, Ota Miho, Matsuo Junko, Kinoshita Yukiko, Ishida Ikki, Hattori Kotaro, Okazaki Mitsutoshi, Arima Kunimasa, Kunugi Hiroshi

Abstract excerpt

While research on remission in schizophrenia has gained attention, personality characteristics associated with remission in schizophrenia have been under-studied. A functional valine-to-methionine (Val158Met) polymorphism in the catechol-O-methyltransferase (COMT) gene is shown to modify clinical presentation of schizophrenia despite weak or no association with the disorder itself. Studies also report that this...

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Source

Identifiers

PMID: 24888672
DOI: 10.1016/j.jpsychires.2014.05.006

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Temperament and character in remitted and symptomatic patients with schizophrenia: modulation by the COMT Val158Met genotype.PMID 24888672Read ↗

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Association study of catechol-O-methyltransferase Val158Met polymorphism with personality traits in Japanese healthy volunteers.Semantic proximity Read ↗

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