DNA Methylation of Human Telomerase Reverse Transcriptase Associated With Leukocyte Telomere Length Shortening in Hyperhomocysteinemia-Type Hypertension in Humans and in a Rat Model

Abstract excerpt

BACKGROUND: Elevated homocysteine (Hcy) levels might play a role in the development of essential hypertension (EH). Telomere dynamics provide valuable insight into the pathogenesis of age-related diseases. The contribution of Hcy to leukocyte telomere length (LTL) shortening in EH and the underlying mechanism was examined. METHODS AND RESULTS: LTL (ratio of the copy number of telomere [T] repeats to that of a...

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