Article
Autophagy inhibition improves chemosensitivity in BRAF(V600E) brain tumors.
Cancer discovery - 1 Jul 2014
Levy Jean M Mulcahy, Thompson Joshua C, Griesinger Andrea M, Amani Vladimir, Donson Andrew M, Birks Diane K, Morgan Michael J, Mirsky David M, Handler Michael H, Foreman Nicholas K, Thorburn Andrew
Abstract excerpt
UNLABELLED: Autophagy inhibition is a potential therapeutic strategy in cancer, but it is unknown which tumors will benefit. The BRAF(V600E) mutation has been identified as important in pediatric central nervous system (CNS) tumors and is known to affect autophagy in other tumor types. We evaluated CNS tumor cells with BRAF(V600E) and found that mutant (but not wild-type) cells display high rates of induced...
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