Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genome engineering empowers the diatom Phaeodactylum tricornutum for biotechnology.

Nature communications - 29 May 2014

Daboussi Fayza, Leduc Sophie, Maréchal Alan, Dubois Gwendoline, Guyot Valérie, Perez-Michaut Christophe, Amato Alberto, Falciatore Angela, Juillerat Alexandre, Beurdeley Marine, Voytas Daniel F, Cavarec Laurent, Duchateau Philippe

Abstract excerpt

Diatoms, a major group of photosynthetic microalgae, have a high biotechnological potential that has not been fully exploited because of the paucity of available genetic tools. Here we demonstrate targeted and stable modifications of the genome of the marine diatom Phaeodactylum tricornutum, using both meganucleases and TALE nucleases. When nuclease-encoding constructs are co-transformed with a selectable marker,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biotechnology
Share to Diatoms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Breaks, Double-Stranded

Share to Endonucleases

Share to Genetic Engineering

Share to Mutation Rate

Share to Tandem Mass Spectrometry

Share to Triglycerides

Source

Identifiers

PMID: 24871200
DOI: 10.1038/ncomms4831

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genome engineering empowers the diatom Phaeodactylum tricornutum for biotechnology.PMID 24871200Read ↗

Generation of Mutants of Nuclear-Encoded Plastid Proteins Using CRISPR/Cas9 in the Diatom Phaeodactylum tricornutum.Semantic proximity Read ↗

Rapid method for generating designer algal mitochondrial genomesSemantic proximity Read ↗

Expanding the DNA editing toolbox: novel lambda integrase variants targeting microalgal and human genome sequencesSemantic proximity Read ↗

Highly efficient genome editing using CRISPR/Cas9 ribonucleoprotein in the marine oleaginous diatom Fistulifera solaris.Semantic proximity Read ↗

Photo-Oxidative Stress-Driven Mutagenesis and Adaptive Evolution on the Marine Diatom Phaeodactylum tricornutum for Enhanced Carotenoid Accumulation.Semantic proximity Read ↗

Gene silencing in the marine diatom Phaeodactylum tricornutum.Semantic proximity Read ↗

Random mutagenesis of Phaeodactylum tricornutum using ultraviolet, chemical, and X-radiation demonstrates the need for temporal analysis of phenotype stability.Semantic proximity Read ↗

Identification of a triacylglycerol lipase in the diatom Phaeodactylum tricornutum.Semantic proximity Read ↗

Delta-5 elongase knockout reduces DHA and TAG synthesis coupled with an increase of heat sensitivity in a marine diatomSemantic proximity Read ↗

PHYCUT: Scalable multiplex CRISPR/Cas9 editing for genome engineering in the diatom <i>Phaeodactylum tricornutum</i>Semantic proximity Read ↗

Identification of the UMP synthase gene by establishment of uracil auxotrophic mutants and the phenotypic complementation system in the marine diatom Phaeodactylum tricornutum.Semantic proximity Read ↗

TALENs mediate efficient and heritable mutation of endogenous genes in the marine annelid Platynereis dumerilii.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.