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Article

Environmental enrichment restores CA1 hippocampal LTP and reduces severity of seizures in epileptic mice.

Experimental neurology - 1 Nov 2014

Morelli Emanuela, Ghiglieri Veronica, Pendolino Valentina, Bagetta Vincenza, Pignataro Annabella, Fejtova Anna, Costa Cinzia, Ammassari-Teule Martine, Gundelfinger Eckart D, Picconi Barbara, Calabresi Paolo

Abstract excerpt

We have analyzed the effects of environmental enrichment (EE) in a seizure-prone mouse model in which the genetic disruption of the presynaptic protein Bassoon leads to structural and functional alterations in the hippocampus and causes early spontaneous seizures mimicking human neurodevelopmental disorders. One-month EE starting at P21 reduced seizure severity, preserved long-term potentiation (LTP) and...

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PMID: 24858730
DOI: 10.1016/j.expneurol.2014.05.010

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