Article
Development of a multiplex and cost-effective genotype test toward more personalized medicine for the antiplatelet drug clopidogrel.
International journal of molecular sciences - 5 May 2014
Jeong Hye-Eun, Lee Su-Jun, Cha Eun-Young, Kim Eun-Young, Kim Ho-Sook, Song Young Hwan, Shin Jae-Gook
Abstract excerpt
There has been a wide range of inter-individual variations in platelet responses to clopidogrel. The variations in response to clopidogrel can be driven by genetic polymorphisms involved in the pathway of absorption, distribution, metabolism, excretion, and the target receptor P2Y12. A set of genetic variants known for causing variations in clopidogrel responses was selected, which included CYP2C19*2, *3, *17,...
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