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Article

Counseling patients with succinate dehydrogenase subunit defects: genetics, preventive guidelines, and dealing with uncertainty.

Journal of pediatric endocrinology & metabolism : JPEM - 1 Sept 2014

Raygada Margarita, King Kathryn S, Adams Karen T, Stratakis Constantine A, Pacak Karel

Abstract excerpt

The discovery that mutations in the succinate dehydrogenase (SDH) complex subunit (SDHA, B/C/D/AF2) genes predispose patients to the development of tumors has led to the identification of a large population of patients and relatives at risk for developing malignancies. The most frequent conditions associated with these mutations are the familial paraganglioma syndromes. Other tumors that are frequently associated...

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Source

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Identifiers

PMID: 24854530
DOI: 10.1515/jpem-2013-0369
PMCID: PMC4718145

Genes

SDHA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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