Article
Bacterial defense systems and host ecology drive the evolution of intra-species lineages.
Cell reports - 24 Feb 2026
Gorzynski Jamie, Harling-Lee Joshua D, Figueroa Wendy, Alves Joana, Yebra Gonzalo, Freeman Tom, Penadés José R, Fitzgerald J Ross
Abstract excerpt
Horizontal gene transfer (HGT) is a major driver of diversity in bacterial populations. However, our understanding of its impact on the evolution of intra-species lineages is limited. The multi-host bacterial pathogen Staphylococcus aureus is differentiated into genetic lineages known as clonal complexes (CC) with variable host and disease tropisms. Here, we demonstrate that CCs exhibit extensive variation in...
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