Article
The roles of circulating high-density lipoproteins and trophic hormones in the phenotype of knockout mice lacking the steroidogenic acute regulatory protein.
Molecular endocrinology (Baltimore, Md.) - 1 Oct 2002
Ishii Tomohiro, Hasegawa Tomonobu, Pai Chin-I, Yvgi-Ohana Natalie, Timberg Rina, Zhao Liping, Majdic Gregor, Chung Bon-chu, Orly Joseph, Parker Keith L
Abstract excerpt
The steroidogenic acute regulatory protein (StAR) is essential for the regulated production of steroid hormones, mediating the translocation of intracellular cholesterol to the inner mitochondrial membrane where steroidogenesis begins. Steroidogenic cells lacking StAR have impaired steroidogenesis and progressively accumulate lipid, ultimately causing cytopathic changes and deterioration of steroidogenic...
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