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Article

Berberine induces apoptosis in human multiple myeloma cell line U266 through hypomethylation of p53 promoter

7 Nov 2013

Abstract excerpt

Berberine has multiple pharmacological activities, such as anti-oxidative, anti-inflammation and anticancer activity. It reduces the proliferation and induces apoptosis in the multiple myeloma cell line, U266. Here we explored the detailed mechanism by analysing the gene expression profiles in U266 treated with or without berberine. DNMT1 andDNMT3B, encoding for a highly conserved member of the DNA...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 24843889
DOI: 10.1002/cbin.10206

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