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Article

Regulation of p53‐targeting microRNAs by polycyclic aromatic hydrocarbons: Implications in the etiology of multiple myeloma

6 May 2014

Abstract excerpt

Multiple myeloma (MM) is a common and deadly cancer of blood plasma cells. A unique feature of MM is the extremely low somatic mutation rate of the p53 tumor suppressor gene, in sharp contrast with about half of all human cancers where this gene is frequently mutated. Eleven miRNAs have been reported to repress p53 through direct interaction with the 3' untranslated region. The expression of nine of them is...

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PMID: 24798859
DOI: 10.1002/mc.22175

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