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Article

Tunability and noise dependence in differentiation dynamics.

Science (New York, N.Y.) - 23 Mar 2007

Süel Gürol M, Kulkarni Rajan P, Dworkin Jonathan, Garcia-Ojalvo Jordi, Elowitz Michael B

Abstract excerpt

The dynamic process of differentiation depends on the architecture, quantitative parameters, and noise of underlying genetic circuits. However, it remains unclear how these elements combine to control cellular behavior. We analyzed the probabilistic and transient differentiation of Bacillus subtilis cells into the state of competence. A few key parameters independently tuned the frequency of initiation and the...

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PMID: 17379809
DOI: 10.1126/science.1137455

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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