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Article

Hepatic steatosis and PNPLA3 I148M variant are associated with serum Fetuin-A independently of insulin resistance.

European journal of clinical investigation - 1 Jul 2014

Rametta Raffaela, Ruscica Massimiliano, Dongiovanni Paola, Macchi Chiara, Fracanzani Anna L, Steffani Liliana, Fargion Silvia, Magni Paolo, Valenti Luca

Abstract excerpt

BACKGROUND & AIMS: Fetuin-A is a liver-derived peptide associated with insulin resistance. Aim of this cross-sectional study was to evaluate whether Fetuin-A is increased in patients with nonalcoholic fatty liver disease (NAFLD) vs. healthy subjects without metabolic abnormalities and the association with insulin resistance and liver damage. To investigate the causal relationship between fatty liver and Fetuin-A,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 24828988
DOI: 10.1111/eci.12280

Genes

PNPLA3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Hepatic steatosis and PNPLA3 I148M variant are associated with serum Fetuin-A independently of insulin resistance.PMID 24828988Read ↗

Non-alcoholic fatty liver disease: causes, diagnosis, cardiometabolic consequences, and treatment strategies.Semantic proximity Read ↗

PNPLA3 I148M variant in nonalcoholic fatty liver disease: demographic and ethnic characteristics and the role of the variant in nonalcoholic fatty liver fibrosis.Semantic proximity Read ↗

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Fetuin-A as a Link Between Dyslipidemia and Cardiovascular Risk in Type 2 Diabetes: A Metabolic Insight for Clinical PracticeSemantic proximity Read ↗

A Perspective on Metabolic Syndrome and Nonalcoholic Fatty Liver Disease.Semantic proximity Read ↗

I148M variant in PNPLA3 reduces central adiposity and metabolic disease risks while increasing nonalcoholic fatty liver disease.Semantic proximity Read ↗

Healthy PNPLA3 risk allele carriers present with unexpected body fat composition. A study of one thousand subjects.Semantic proximity Read ↗

Association of fetuin B with markers of liver fibrosis in nonalcoholic fatty liver disease.Semantic proximity Read ↗

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Insulin resistance is an integral feature of MASLD even in the presence of PNPLA3 variantsSemantic proximity Read ↗

PNPLA3 I148M Polymorphism in Patients with Nonalcoholic Fatty Liver Disease, Obesity and Prediabetes.Semantic proximity Read ↗

Adipose tissue is inflamed in NAFLD due to obesity but not in NAFLD due to genetic variation in PNPLA3.Semantic proximity Read ↗

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