Article
Mutation analysis of seven known glaucoma-associated genes in Chinese patients with glaucoma.
Investigative ophthalmology & visual science - 13 May 2014
Huang Xiaobo, Li Miaoling, Guo Xiangming, Li Shiqiang, Xiao Xueshan, Jia Xiaoyun, Liu Xing, Zhang Qingjiong
Abstract excerpt
PURPOSE: To evaluate mutations in the MYOC, WDR36, OPTN, OPA1, NTF4, CYP1B1, and LTBP2 genes in a cohort of Chinese patients with primary glaucoma. METHODS: Genomic DNA was prepared from 683 unrelated patients, including 50 with primary congenital glaucoma, 104 with juvenile open-angle glaucoma (JOAG), 186 with primary open-angle glaucoma (POAG), and 343 with primary angle-closure glaucoma (PACG). Mutations in...
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