Article
HBsAg loss in patients treated with peginterferon alfa-2a and adefovir is associated with SLC16A9 gene variation and lower plasma carnitine levels.
Journal of hepatology - 1 Oct 2014
Jansen Louis, de Niet Annikki, Stelma Femke, van Iperen Erik P A, van Dort Karel A, Plat-Sinnige Marjan J Tempelmans, Takkenberg R Bart, Chin Daniel J, Zwinderman A H Koos, Lopatin Uri, Kootstra Neeltje A, Reesink Hendrik W
Abstract excerpt
BACKGROUND & AIMS: Achievement of HBsAg loss remains the hallmark of chronic hepatitis B treatment. In order to identify host factors contributing to treatment-induced HBsAg loss, we performed a genome-wide screen of single nucleotide polymorphisms (SNPs) and studied its immunological consequence. METHODS: Chronic hepatitis B patients (40 HBeAg-positive and 44 HBeAg-negative) treated with peginterferon alfa-2a...
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