Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

<scp>HAUSP</scp>, a novel deubiquitinase for Rb – <scp>MDM</scp>2 the critical regulator

14 May 2014

Abstract excerpt

Tumor suppressor retinoblastoma-associated protein (Rb) is an important cell cycle regulator, arresting cells in early G1. It is commonly inactivated in cancers and its level is maintained during the cell cycle. Rb is regulated by various post-translational modifications such as phosphorylation, acetylation, ubiquitination and so on. Several E3 ligases including murine double minute 2 (MDM2) promote the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to Ocular Oncology and Treatments
Share to Ubiquitin and proteasome pathways

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 24823443
DOI: 10.1111/febs.12843

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

<scp>HAUSP</scp>, a novel deubiquitinase for Rb – <scp>MDM</scp>2 the critical regulatorPMID 24823443Read ↗

Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization.Semantic proximity Read ↗

Emerging insights into HAUSP (USP7) in physiology, cancer and other diseasesSemantic proximity Read ↗

Expression of HAUSP in gliomas correlates with disease progression and survival of patientsSemantic proximity Read ↗

A portrayal of E3 ubiquitin ligases and deubiquitylases in cancerSemantic proximity Read ↗

Skp2: A critical molecule for ubiquitination and its role in cancerSemantic proximity Read ↗

Ubiquitin‐mediated control of oncogene and tumor suppressor gene productsSemantic proximity Read ↗

Emerging regulatory mechanisms in ubiquitin-dependent cell cycle controlSemantic proximity Read ↗

Deubiquitination of Chfr, a checkpoint protein, by USP7/HAUSP regulates its stability and activity.Semantic proximity Read ↗

Down-Regulating HAUS6 Suppresses Cell Proliferation by Activating the p53/p21 Pathway in Colorectal CancerSemantic proximity Read ↗

The Retinoblastoma (RB) Tumor Suppressor: Pushing Back against Genome Instability on Multiple FrontsSemantic proximity Read ↗

Inhibition of deubiquitinases primes glioblastoma cells to apoptosis in vitro and in vivoSemantic proximity Read ↗

Writing and erasing MYC ubiquitination and SUMOylationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.