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Article

Deubiquitination of Chfr, a checkpoint protein, by USP7/HAUSP regulates its stability and activity.

Biochemical and biophysical research communications - 8 Jun 2007

Oh Young Mi, Yoo Soon Ji, Seol Jae Hong

Abstract excerpt

Chfr, a mitotic stress checkpoint, plays an important role in cell cycle progression, tumor suppression and the processes that require the E3 ubiquitin ligase activity mediated by the RING finger domain. Chfr stimulates the formation of polyubiquitin chains by ub-conjugating enzymes, and induces the proteasome-dependent degradation of a number of cellular proteins including Plk1 and Aurora A. In this study, we...

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Source

Identifiers

PMID: 17442268
DOI: 10.1016/j.bbrc.2007.03.193

Genes

USP7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Deubiquitination of Chfr, a checkpoint protein, by USP7/HAUSP regulates its stability and activity.PMID 17442268Read ↗

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