Article
miR-181c regulates the mitochondrial genome, bioenergetics, and propensity for heart failure in vivo.
PloS one - 1 Jan 2014
Das Samarjit, Bedja Djahida, Campbell Nathaniel, Dunkerly Brittany, Chenna Venugopal, Maitra Anirban, Steenbergen Charles
Abstract excerpt
MicroRNAs (miRNAs) are small non-coding RNAs, which inhibit the stability and/or translation of a mRNA. miRNAs have been found to play a powerful role in various cardiovascular diseases. Recently, we have demonstrated that a microRNA (miR-181c) can be encoded in the nucleus, processed to the mature form in the cytosol, translocated into the mitochondria, and ultimately can regulate mitochondrial gene expression....
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