Article
Exome-wide association study of endometrial cancer in a multiethnic population.
PloS one - 1 Jan 2014
Chen Maxine M, Crous-Bou Marta, Setiawan Veronica W, Prescott Jennifer, Olson Sara H, Wentzensen Nicolas, Black Amanda, Brinton Louise, Chen Chu, Chen Constance, Cook Linda S, Doherty Jennifer, Friedenreich Christine M, Hankinson Susan E, Hartge Patricia, Henderson Brian E, Hunter David J, Le Marchand Loic, Liang Xiaolin, Lissowska Jolanta, Lu Lingeng, Orlow Irene, Petruzella Stacey, Polidoro Silvia, Pooler Loreall, Rebbeck Timothy R, Risch Harvey, Sacerdote Carlotta, Schumacher Frederick, Sheng Xin, Shu Xiao-Ou, Weiss Noel S, Xia Lucy, Van Den Berg David, Yang Hannah P, Yu Herbert, Chanock Stephen, Haiman Christopher, Kraft Peter, De Vivo Immaculata
Abstract excerpt
Endometrial cancer (EC) contributes substantially to total burden of cancer morbidity and mortality in the United States. Family history is a known risk factor for EC, thus genetic factors may play a role in EC pathogenesis. Three previous genome-wide association studies (GWAS) have found only one locus associated with EC, suggesting that common variants with large effects may not contribute greatly to EC risk....
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