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Article

Contribution of increased ISG15, ISGylation and deregulated type I IFN signaling in Usp18 mutant mice during the course of bacterial infections.

Genes and immunity - 1 Jan 2000

Dauphinee S M, Richer E, Eva M M, McIntosh F, Paquet M, Dangoor D, Burkart C, Zhang D-E, Gruenheid S, Gros P, Behr M, Malo D

Abstract excerpt

Host genetics has a key role in susceptibility to Salmonella Typhimurium infection. We previously used N-ethyl-N-nitrosourea (ENU) mutagenesis to identify a loss-of-function mutation within the gene ubiquitin-specific peptidase 18 (Usp18(Ity9)), which confers increased susceptibility to Salmonell...

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Source

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Identifiers

PMID: 24807690
DOI: 10.1038/gene.2014.17
PMCID: PMC4111656

Genes

ISG15
USP18

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24807690-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Contribution of increased ISG15, ISGylation and deregulated type I IFN signaling in Usp18 mutant mice during the course of bacterial infections.PMID 24807690Read ↗

N-ethyl-N-nitrosourea-induced mutation in ubiquitin-specific peptidase 18 causes hyperactivation of IFN-αß signaling and suppresses STAT4-induced IFN-γ production, resulting in increased susceptibility to Salmonella typhimurium.Semantic proximity Read ↗

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