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Article

SCF/C-KIT signaling modulates tryptase expression in acute myeloid leukemia cells.

International journal of hematology - 1 Jun 2014

Jin Jingchun, Li Yan, Wang Yue, Wang Pingping, Wang Yazhu

Abstract excerpt

Tryptase is a serine protease with a variety of biological functions. Recently, elevated serum tryptase has been detected in certain patients with acute myeloid leukemia (AML). However, the underlying mechanism for the regulation of tryptase expression remains elusive. In this study, we aimed to investigate the role of stem cell factor (SCF)/C-KIT signaling in regulating the expression of tryptase in AML cells....

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Share to Antineoplastic Combined Chemotherapy Protocols
Share to Gene Expression Regulation, Leukemic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Leukemia, Myeloid, Acute

Share to MAP Kinase Signaling System

Share to Proto-Oncogene Proteins c-kit

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Source

Identifiers

PMID: 24806698
DOI: 10.1007/s12185-014-1586-y

Genes

KIT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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