Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Abnormalities in Early Markers of Muscle Involvement Support a Delay in Myogenesis in Spinal Muscular Atrophy

7 May 2014

Abstract excerpt

Spinal muscular atrophy (SMA) is characterized by loss of motor neurons in the spinal cord that results in muscle denervation and profound weakness in affected patients. We sought evidence for primary muscle involvement in the disease during human development by analyzing the expression of several muscle cytoskeletal components (i.e. slow, fast, and developmental myosin, desmin, and vimentin) in fetal or...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Muscle Physiology and Disorders
Share to Neurogenetic and Muscular Disorders Research
Share to RNA modifications and cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 24806300
DOI: 10.1097/nen.0000000000000078

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Abnormalities in Early Markers of Muscle Involvement Support a Delay in Myogenesis in Spinal Muscular AtrophyPMID 24806300Read ↗

SMN deficiency induces an early non-atrophic myopathy with alterations in the contractile and excitatory coupling machinery of skeletal myofibers in the SMNΔ7 mouse model of spinal muscular atrophySemantic proximity Read ↗

The distribution of SMN protein complex in human fetal tissues and its alteration in spinal muscular atrophySemantic proximity Read ↗

Pre-natal manifestation of systemic developmental abnormalities in spinal muscular atrophy.Semantic proximity Read ↗

Spinal muscular atrophy: a delayed development hypothesisSemantic proximity Read ↗

Pre-symptomatic development of lower motor neuron connectivity in a mouse model of severe spinal muscular atrophySemantic proximity Read ↗

Selective vulnerability of motor neurons and dissociation of pre- and post-synaptic pathology at the neuromuscular junction in mouse models of spinal muscular atrophy.Semantic proximity Read ↗

Survival motor neuron (SMN) protein: role in neurite outgrowth and neuromuscular maturation during neuronal differentiation and developmentSemantic proximity Read ↗

Developmental myosins: expression patterns and functional significanceSemantic proximity Read ↗

Survival motor neuron protein deficiency impairs myotube formation by altering myogenic gene expression and focal adhesion dynamicsSemantic proximity Read ↗

Importance of immunohistochemical evaluation of developmentally regulated myosin heavy chains in human muscle biopsiesSemantic proximity Read ↗

Expression of intermediate filaments at muscle insertions in human fetusesSemantic proximity Read ↗

In vitro and in vivo expression of alpha 7 integrin and desmin define the primary and secondary myogenic lineages.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.