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Article

Pre-symptomatic development of lower motor neuron connectivity in a mouse model of severe spinal muscular atrophy

2 Nov 2009

Abstract excerpt

The childhood motor neuron disease spinal muscular atrophy (SMA) results from reduced expression of the survival motor neuron (SMN) gene. Previous studies using in vitro model systems and lower organisms have suggested that low levels of Smn protein disrupt prenatal developmental processes in lower motor neurons, influencing neuronal outgrowth, axon branching and neuromuscular connectivity. The extent to which...

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Identifiers

PMID: 19884170
DOI: 10.1093/hmg/ddp506

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