Article
Within-host evolution of Pseudomonas aeruginosa reveals adaptation toward iron acquisition from hemoglobin.
mBio - 6 May 2014
Marvig Rasmus Lykke, Damkiær Søren, Khademi S M Hossein, Markussen Trine M, Molin Søren, Jelsbak Lars
Abstract excerpt
ABSTRACT Pseudomonas aeruginosa airway infections are a major cause of mortality and morbidity of cystic fibrosis (CF) patients. In order to persist, P. aeruginosa depends on acquiring iron from its host, and multiple different iron acquisition systems may be active during infection. This includes the pyoverdine siderophore and the Pseudomonas heme utilization (phu) system. While the regulation and mechanisms of...
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