Article
Multiple rare variants in different genes account for multifactorial inherited susceptibility to colorectal adenomas.
Proceedings of the National Academy of Sciences of the United States of America - 9 Nov 2004
Fearnhead Nicola S, Wilding Jennifer L, Winney Bruce, Tonks Susan, Bartlett Sylvia, Bicknell David C, Tomlinson Ian P M, Mortensen Neil J McC, Bodmer Walter F
Abstract excerpt
Clear-cut inherited Mendelian traits, such as familial adenomatous polyposis or hereditary nonpolyposis colorectal cancer, account for <4% of colorectal cancers. Another 20% of all colorectal cancers are thought to occur in individuals with a significant inherited multifactorial susceptibility to colorectal cancer that is not obviously familial. Incompletely penetrant, comparatively rare missense variants in the...
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