Article
Human dendritic cell maturation and cytokine secretion upon stimulation with Bordetella pertussis filamentous haemagglutinin.
Microbes and infection - 1 Jul 2014
Dirix Violette, Mielcarek Nathalie, Debrie Anne-Sophie, Willery Eve, Alonso Sylvie, Versheure Virginie, Mascart Françoise, Locht Camille
Abstract excerpt
In addition to antibodies, Th1-type T cell responses are also important for long-lasting protection against pertussis. However, upon immunization with the current acellular vaccines, many children fail to induce Th1-type responses, potentially due to immunomodulatory effects of some vaccine antigens, such as filamentous haemagglutinin (FHA). We therefore analysed the ability of FHA to modulate immune functions of...
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