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Simian Virus 40 Large T Antigen Induces IFN-Stimulated Genes through ATR Kinase

6 May 2014

Abstract excerpt

Polyomaviruses encode a large T Ag (LT), a multifunctional protein essential for the regulation of both viral and host cell gene expression and productive viral infection. Previously, we have shown that stable expression of LT protein results in upregulation of genes involved in the IFN induction and signaling pathway. In this study, we focus on the cellular signaling mechanism that leads to the induction of IFN...

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PMID: 24799566
DOI: 10.4049/jimmunol.1303470

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