Article
Polymorphisms in regulators of xenobiotic transport and metabolism genes PXR and CAR do not affect multiple myeloma risk: a case-control study in the context of the IMMEnSE consortium.
Journal of human genetics - 1 Mar 2013
Martino Alessandro, Sainz Juan, Manuel Reis Rui, Moreno Victor, Buda Gabriele, Lesueur Fabienne, Marques Herlander, García-Sanz Ramón, Ríos Rafael, Stein Angelika, Dumontet Charles, Gemignani Federica, Maria Rossi Anna, Landi Stefano, Jurado Manuel, Petrini Mario, Jamroziak Krzysztof, Campa Daniele, Canzian Federico
Abstract excerpt
The exposure to pesticides and toxic compounds in xenobiotic transport and metabolism genes has been shown to affect risk of developing multiple myeloma (MM). Therefore, we hypothesized that genetic variations in xenobiotic transport and metabolism regulator genes PXR (NR1I2) and CAR (NR1I3) coul...
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