Article
In vivo dopaminergic and serotonergic dysfunction in DCTN1 gene mutation carriers.
Movement disorders : official journal of the Movement Disorder Society - 1 Aug 2014
Felicio Andre C, Dinelle Katherine, Agarwal Pankaj A, McKenzie Jessamyn, Heffernan Nicole, Road Jeremy D, Appel-Cresswell Silke, Wszolek Zbigniew K, Farrer Matthew J, Schulzer Michael, Sossi Vesna, Stoessl A Jon
Abstract excerpt
INTRODUCTION: We used positron emission tomography (PET) to assess dopaminergic and serotonergic terminal density in three subjects carrying a mutation in the DCT1 gene, two clinically affected with Perry syndrome. METHODS: All subjects had brain imaging using 18F-6-fluoro-l-dopa (FDOPA, dopamine synthesis and storage), (+)-11C-dihydrotetrabenazine (DTBZ, vesicular monoamine transporter type 2), and...
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