Article
Tuberculin skin test reversion following isoniazid preventive therapy reflects diversity of immune response to primary Mycobacterium tuberculosis infection.
PloS one - 1 Jan 2014
Johnson Denise F, Malone LaShaunda L, Zalwango Sarah, Mukisa Oketcho Joy, Chervenak Keith A, Thiel Bonnie, Mayanja-Kizza Harriet, Stein Catherine M, Boom W Henry, Lancioni Christina L
Abstract excerpt
RATIONALE: Healthy household contacts (HHC) of individuals with Tuberculosis (TB) with Tuberculin Skin Test (TST) conversions are considered to harbor latent Mycobacterium tuberculosis (Mtb), and at risk for TB. The immunologic, clinical, and public health implications of TST reversions that occur following Isoniazid preventive therapy (IPT) remain controversial. OBJECTIVES: To measure frequency of TST reversion...
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