Article
Progression to active tuberculosis, but not transmission, varies by Mycobacterium tuberculosis lineage in The Gambia.
The Journal of infectious diseases - 1 Oct 2008
de Jong Bouke C, Hill Philip C, Aiken Alex, Awine Timothy, Antonio Martin, Adetifa Ifedayo M, Jackson-Sillah Dolly J, Fox Annette, Deriemer Kathryn, Gagneux Sebastien, Borgdorff Martien W, McAdam Keith P W J, Corrah Tumani, Small Peter M, Adegbola Richard A
Abstract excerpt
BACKGROUND: There is considerable variability in the outcome of Mycobacterium tuberculosis infection. We hypothesized that Mycobacterium africanum was less likely than M. tuberculosis to transmit and progress to tuberculosis disease. METHODS: In a cohort study of patients with tuberculosis and their household contacts in The Gambia, we categorized 1808 HIV-negative tuberculosis contacts according to exposure to...
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