Article
In silico prediction of mutant HIV-1 proteases cleaving a target sequence.
PloS one - 1 Jan 2014
Jensen Jan H, Willemoës Martin, Winther Jakob R, De Vico Luca
Abstract excerpt
HIV-1 protease represents an appealing system for directed enzyme re-design, since it has various different endogenous targets, a relatively simple structure and it is well studied. Recently Chaudhury and Gray (Structure (2009) 17: 1636-1648) published a computational algorithm to discern the specificity determining residues of HIV-1 protease. In this paper we present two computational tools aimed at re-designing...
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