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Article

Structural and energetic analysis on the complexes of clinically isolated subtype C HIV-1 proteases and approved inhibitors by molecular dynamics simulation.

The journal of physical chemistry. B - 14 Jan 2010

Matsuyama Shou, Aydan Ay, Ode Hirotaka, Hata Masayuki, Sugiura Wataru, Hoshino Tyuji

Abstract excerpt

HIV-1 has a large genetic diversity. Subtype B HIV-1 is commonly found in patients in developed countries. In contrast, an increasing number of patients are infected with the non-B subtype viruses, especially with subtype C HIV-1, in developing countries. It remains to be clarified how mutations or polymorphisms in non-B subtype HIV-1 influence the efficacy of the approved inhibitors. In this study, we have...

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Source

Identifiers

PMID: 20055526
DOI: 10.1021/jp908314f

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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