Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Paths of resistance to EGFR inhibitors: is NF enough?

Cancer discovery - 1 May 2014

Maertens Ophélia, Cichowski Karen

Abstract excerpt

Although the majority of patients with EGFR-mutant lung cancer respond well to EGF receptor (EGFR) tyrosine kinase inhibitors (TKI), all patients eventually develop resistance. The mechanism of acquired resistance is still unknown for a considerable subset of cases. This study reveals the NF1 tumor suppressor gene as a new mediator of resistance to EGFR TKIs and provides a mechanistic rationale for developing...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antineoplastic Agents
Share to Drug Resistance, Neoplasm
Share to ErbB Receptors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to EGF gene

Share to Lung Neoplasms

Share to Mutation

Share to Neurofibromin 1

Share to Protein Kinase Inhibitors

Source

Identifiers

PMID: 24795011
DOI: 10.1158/2159-8290.CD-14-0286

Genes

EGFR
EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 8 closest

Paths of resistance to EGFR inhibitors: is NF enough?PMID 24795011Read ↗

A genome-scale RNA interference screen implicates NF1 loss in resistance to RAF inhibition.Semantic proximity Read ↗

YAP signaling promotes resistance to MEK and AKT inhibition in <i>NF1</i> -related MPNSTsSemantic proximity Read ↗

RASA1/NF1-Mutant Lung Cancer: Racing to the Clinic?Semantic proximity Read ↗

Increased expression of miR-641 contributes to erlotinib resistance in non-small-cell lung cancer cells by targeting NF1.Semantic proximity Read ↗

Inactivation of NF1 Promotes Resistance to EGFR Inhibition in KRAS/NRAS/BRAFV600 -Wild-Type Colorectal Cancer.Semantic proximity Read ↗

Mutations in ALK signaling pathways conferring resistance to ALK inhibitor treatment lead to collateral vulnerabilities in neuroblastoma cells.Semantic proximity Read ↗

The tumor suppressor neurofibromin confers sensitivity to apoptosis by Ras-dependent and Ras-independent pathways.Semantic proximity Read ↗

Resiliency of lung cancers to EGFR inhibitor treatment unveiled, offering opportunities to divide and conquer EGFR inhibitor resistance.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.