Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A genome-scale RNA interference screen implicates NF1 loss in resistance to RAF inhibition.

Cancer discovery - 1 Mar 2013

Whittaker Steven R, Theurillat Jean-Philippe, Van Allen Eliezer, Wagle Nikhil, Hsiao Jessica, Cowley Glenn S, Schadendorf Dirk, Root David E, Garraway Levi A

Abstract excerpt

RAF inhibitors such as vemurafenib and dabrafenib block BRAF-mediated cell proliferation and achieve meaningful clinical benefit in the vast majority of patients with BRAF(V600E)-mutant melanoma. However, some patients do not respond to this regimen, and nearly all progress to therapeutic resista...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Proliferation
Share to Drug Resistance, Neoplasm
Share to MAP Kinase Signaling System

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Melanoma

Share to Neurofibromin 1

Share to Protein Kinase Inhibitors

Share to Proto-Oncogene Proteins B-raf

Share to RNA Interference

Source

Open in PubMed Open full text

Identifiers

PMID: 23288408
DOI: 10.1158/2159-8290.CD-12-0470
PMCID: PMC3606893

Genes

BRAF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23288408-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A genome-scale RNA interference screen implicates NF1 loss in resistance to RAF inhibition.PMID 23288408Read ↗

Inactivation of NF1 Promotes Resistance to EGFR Inhibition in KRAS/NRAS/BRAFV600 -Wild-Type Colorectal Cancer.Semantic proximity Read ↗

NF1 alterations in cancers: therapeutic implications in precision medicineSemantic proximity Read ↗

Functional Genomic Screening Independently Identifies CUL3 as a Mediator of Vemurafenib Resistance via Src-Rac1 Signaling AxisSemantic proximity Read ↗

Genome-scale CRISPR-Cas9 knockout screening in hepatocellular carcinoma with lenvatinib resistanceSemantic proximity Read ↗

Neurofibromatosis 1.Semantic proximity Read ↗

Loss of NF1 in Cutaneous Melanoma Is Associated with RAS Activation and MEK DependenceSemantic proximity Read ↗

The genetic landscape of clinical resistance to RAF inhibition in metastatic melanoma.Semantic proximity Read ↗

Exome sequencing identifies recurrent mutations in NF1 and RASopathy genes in sun-exposed melanomas.Semantic proximity Read ↗

Deconvoluting Mechanisms of Acquired Resistance to RAF Inhibitors in BRAFV600E-Mutant Human Glioma.Semantic proximity Read ↗

Identification of BRAF Inhibitor Resistance-associated lncRNAs Using Genome-scale CRISPR-Cas9 Transcriptional Activation Screening.Semantic proximity Read ↗

Nf1-Mutant Tumors Undergo Transcriptome and Kinome Remodeling after Inhibition of either mTOR or MEK.Semantic proximity Read ↗

NF1 Loss Promotes EGFR Activation and Confers Sensitivity to EGFR Inhibition in NF1-Mutant Melanoma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.