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Article

Psychiatric phenotypes associated with hyperprolinemia: A systematic review.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Jul 2021

Namavar Yasmin, Duineveld Denise Joanne, Both Geertje Ingena Angelique, Fiksinski Ania Maria, Vorstman Jacob Abraham Schrey, Verhoeven-Duif Nanda Margriet, Zinkstok Janneke Rozemarijn

Abstract excerpt

Hyperprolinemia Type I and II are genetic metabolic disorders caused by disrupted proline degradation. It has been suggested that hyperprolinemia is associated with increased risk of developmental and mental disorders but detailed information on the psychiatric phenotype in hyperprolinemic patients is limited. Following PRISMA guidelines, we carried out a systematic review to clarify psychiatric phenotypes in...

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PMID: 34302426
DOI: 10.1002/ajmg.b.32869

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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