Article
Synergistic effect of anti and pro-inflammatory cytokine genes and their promoter polymorphism with ST-elevation of myocardial infarction.
Gene - 10 Jul 2014
Biswas Santanu, Ghoshal Pradip Kumar, Mandal Nripendranath
Abstract excerpt
BACKGROUND: The single-gene approach in association studies of polygenic diseases such as acute myocardial infarction (AMI) is likely to provide limited value. Interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and interleukin-10 (IL-10) plasma levels may be genetically influenced. AIM: We evaluate the impact of single nucleotide polymorphism of the promoter region of these genes, as well as reciprocal...
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