Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Lifespan Extension by Methionine Restriction Requires Autophagy-Dependent Vacuolar Acidification

1 May 2014

Abstract excerpt

Reduced supply of the amino acid methionine increases longevity across species through an as yet elusive mechanism. Here, we report that methionine restriction (MetR) extends yeast chronological lifespan in an autophagy-dependent manner. Single deletion of several genes essential for autophagy (ATG5, ATG7 or ATG8) fully abolished the longevity-enhancing capacity of MetR. While pharmacological or genetic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autophagy in Disease and Therapy
Share to Fungal and yeast genetics research
Share to Genetics, Aging, and Longevity in Model Organisms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 24785424
DOI: 10.1371/journal.pgen.1004347

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Lifespan Extension by Methionine Restriction Requires Autophagy-Dependent Vacuolar AcidificationPMID 24785424Read ↗

Extension of Cellular Lifespan by Methionine Restriction Involves Alterations in Central Carbon Metabolism and Is Mitophagy-DependentSemantic proximity Read ↗

Essential role for autophagy in life span extensionSemantic proximity Read ↗

Extension of chronological life span in yeast by decreased TOR pathway signaling.Semantic proximity Read ↗

Autophagy is required for extension of yeast chronological life span by rapamycinSemantic proximity Read ↗

Enhancing lifespan of budding yeast by pharmacological lowering of amino acid poolsSemantic proximity Read ↗

Calorie Restriction Suppresses Premature Ageing in Pro-Apoptotic Yeast Mutants Through an Autophagy-Independent Mechanism.Semantic proximity Read ↗

Methionine Restriction Activates the Retrograde Response and Confers Both Stress Tolerance and Lifespan Extension to Yeast, Mouse and Human CellsSemantic proximity Read ↗

Stimulating S-adenosyl-l-methionine synthesis extends lifespan via activation of AMPK.Semantic proximity Read ↗

Phosphate Restriction Promotes Longevity via Activation of Autophagy and the Multivesicular Body PathwaySemantic proximity Read ↗

V-ATPase Disassembly at the Yeast Lysosome-Like Vacuole Is a Phenotypic Driver of Lysosome Dysfunction in Replicative AgingSemantic proximity Read ↗

V-ATPase Disassembly at the Yeast Lysosome-Like Vacuole Is a Phenotypic Driver of Lysosome Dysfunction in Replicative Aging.Semantic proximity Read ↗

8-Dehydrosterols induce membrane traffic and autophagy defects through V-ATPase dysfunction in Saccharomyces cerevisae.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.