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Article

Low doses of flagellin-L2 multimer vaccines protect against challenge with diverse papillomavirus genotypes.

Vaccine - 12 Jun 2014

Kalnin Kirill, Tibbitts Timothy, Yan Yanhua, Stegalkina Svetlana, Shen Lihua, Costa Victor, Sabharwal Robert, Anderson Stephen F, Day Patricia M, Christensen Neil, Schiller John T, Jagu Subhashini, Roden Richard B S, Almond Jeffrey, Kleanthous Harold

Abstract excerpt

Genetically modified bacterial flagellin (Fla), a Toll-like receptor-5 (TLR5) ligand, was evaluated as a fusion partner for human papillomavirus (HPV) L2-based immunogens in two animal challenge models; either cutaneous inoculation of rabbits with HPV 'quasivirions' containing cottontail rabbit papillomavirus (CRPV) genomes that induce warts, or intra-vaginal inoculation of mice with HPV 'pseudovirions'...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24780250
DOI: 10.1016/j.vaccine.2014.04.032
PMCID: PMC4332780

Genes

TLR5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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