Article
Incorporation of RG1 epitope concatemers into a self-adjuvanting Flagellin-L2 vaccine broaden durable protection against cutaneous challenge with diverse human papillomavirus genotypes.
Vaccine - 5 Sept 2017
Kalnin Kirill, Chivukula Sudha, Tibbitts Timothy, Yan Yanhua, Stegalkina Svetlana, Shen Lihua, Cieszynski Jacqueline, Costa Victor, Sabharwal Robert, Anderson Stephen F, Christensen Neil, Jagu Subhashini, Roden Richard B S, Kleanthous Harry
Abstract excerpt
AIM: To achieve durable and broad protection against human papillomaviruses by vaccination with multimers of minor capsid antigen L2 using self-adjuvanting fusions with the toll-like receptor-5 (TLR5) ligand bacterial flagellin (Fla) instead of co-formulation with alum. METHODS: Fla fusions with L2 protective epitopes comprising residues 11-200, 11-88 and/or 17-38 of a single or multiple HPV types were produced...
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