Article
Status of Anaplastic Lymphoma Kinase (ALK) in malignant mesothelioma.
Anticancer research - 1 May 2014
Varesano Serena, Leo Claudio, Boccardo Simona, Salvi Sandra, Truini Mauro, Ferro Paola, Fedeli Franco, Canessa Pier Aldo, Dessanti Paolo, Pistillo Maria Pia, Roncella Silvio
Abstract excerpt
BACKGROUND: Malignant mesothelioma (MM) is a particularly aggressive type of primary tumor, associated with exposure to asbestos, and characterized by high mortality. To date, there is no curative therapy for MM. The receptor anaplastic lymphoma kinase (ALK) was found to be mutated in many cases of cancer and used as a target in biological therapies. We investigated whether this pharmacological treatment could...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.