Article
Combination effect of cytochrome P450 1A1 gene polymorphisms on uterine leiomyoma: A case-control study.
Bosnian journal of basic medical sciences - 2 Aug 2016
Salimi Saeedeh, Sajadian Mojtaba, Khodamian Maryam, Yazdi Atefeh, Rezaee Soodabeh, Mohammadpour-Gharehbagh Abbas, Mokhtari Mojgan, Yaghmaie Minoo
Abstract excerpt
Uterine leiomyoma (UL) is an estrogen-dependent neoplasm of the uterus, and estrogen metabolizing enzymes affect its progression. This study aimed to evaluate the association between two single-nucleotide polymorphisms of cytochrome P450 1A1 (CYP1A1) gene and UL risk. The study consisted of 105 patients with UL and 112 healthy women as controls. Ile462Val (A/G) and Asp449Asp (T/C) polymorphisms of CYP1A1 gene...
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