Article
Pharmacogenetic analysis of canonical versus noncanonical pathway of NF-kB in Crohn's disease patients under anti-tumor necrosis factor-α treatment.
Pharmacogenetics and genomics - 1 Aug 2022
Stavrou Eleana F, Chatzopoulou Fani, Antonatos Charalabos, Pappa Panagiota, Makridou Eutychia, Oikonomou Konstantinos, Kapsoritakis Andreas, Potamianos Petros S, Karmiris Konstantinos, Tzathas Charalambos, Chatzidimitriou Dimitris, Vizirianakis Ioannis S, Vasilopoulos Yiannis
Abstract excerpt
OBJECTIVES: This study explores the potential of gene polymorphisms in the canonical and noncanonical NF-kB signaling pathway as a prediction biomarker of anti-tumor necrosis factor (TNF)α response in Crohn's patients. MATERIALS AND METHODS: A total of 109 Greek patients with Crohn's disease (CD) were recruited, and the genotype of TLR2 rs3804099, LTA rs909253, TLR4 rs5030728, and MAP3K14/NIK rs7222094 single...