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Article

The COMT Val158Met polymorphism regulates the effect of a dopamine antagonist on the feedback-related negativity.

Psychophysiology - 1 Aug 2014

Mueller Erik M, Burgdorf Christin, Chavanon Mira-Lynn, Schweiger Desiree, Hennig Jürgen, Wacker Jan, Stemmler Gerhard

Abstract excerpt

Consistent with dopamine accounts of internal and external feedback processing, prior work showed that the dopamine D2 receptor antagonist sulpiride modulates the relationship between the dopaminergic COMT Val158Met polymorphism and the error-related negativity (ERN). Here, we tested in an independent sample whether this Gene × Substance interaction generalizes to the feedback-related negativity (FRN), which...

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Source

Identifiers

PMID: 24773408
DOI: 10.1111/psyp.12226

Genes

COMT
MET

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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