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Article

Genetic influences on cognitive endophenotypes in schizophrenia.

Schizophrenia research - 1 Jun 2014

Yeo Ronald A, Gangestad Steven W, Walton Esther, Ehrlich Stefan, Pommy Jessica, Turner Jessica A, Liu Jingyu, Mayer Andrew R, Schulz S Charles, Ho Beng-Choon, Bustillo Juan R, Wassink Thomas H, Sponheim Scott R, Morrow Eric M, Calhoun Vince D

Abstract excerpt

BACKGROUND: Cognitive deficits are prominent in schizophrenia and represent promising endophenotypes for genetic research. METHODS: The current study investigated the importance of two conceptually distinct genetic aggregates, one based on copy number variations (uncommon deletion burden), and one based on single nucleotide polymorphisms identified in recent risk studies (genetic risk score). The impact of these...

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PMID: 24768440
DOI: 10.1016/j.schres.2014.03.022
PMCID: PMC4699552

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