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Article

Defective remodeling and maturation of the lymphatic vasculature in Angiopoietin-2 deficient mice.

Developmental biology - 15 Jul 2008

Dellinger Michael, Hunter Robert, Bernas Michael, Gale Nicholas, Yancopoulos George, Erickson Robert, Witte Marlys

Abstract excerpt

Molecular mechanisms regulating the remodeling of the lymphatic vasculature from an immature plexus of vessels to a hierarchal network of initial and collecting lymphatics are not well understood. One gene thought to be important for this process is Angiopoietin-2 (Ang-2). Ang2(-/-) mice have previously been reported to exhibit an abnormal lymphatic phenotype but the precise nature of the lymphatic defects and...

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Identifiers

PMID: 18514180
DOI: 10.1016/j.ydbio.2008.04.024
PMCID: PMC2536689

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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